Different contribution of BRINP3 gene in chronic periodontitis and peri-implantitis: a cross-sectional study
Identifieur interne : 001241 ( Main/Exploration ); précédent : 001240; suivant : 001242Different contribution of BRINP3 gene in chronic periodontitis and peri-implantitis: a cross-sectional study
Auteurs : Priscila L. Casado ; Diego P. Aguiar ; Lucas C. Costa ; Marcos A. Fonseca ; Thays Cs Vieira ; Claudia Ck Alvim-Pereira ; Fabiano Alvim-Pereira ; Kathleen Deeley [États-Unis] ; José M. Granjeiro ; Paula C. Trevilatto [Brésil] ; Alexandre R. Vieira [États-Unis]Source :
- BMC Oral Health [ 1472-6831 ] ; 2015.
Abstract
Peri-implantitis is a chronic inflammation, resulting in loss of supporting bone around implants. Chronic periodontitis is a risk indicator for implant failure. Both diseases have a common etiology regarding inflammatory destructive response.
The aim of this work was to investigate the association between
Periodontal and peri-implant examinations were performed in 215 subjects, divided into: healthy (without chronic periodontitis and peri-implantitis, n = 93); diseased (with chronic periodontitis and peri-implantitis, n = 52); chronic periodontitis only (n = 36), and peri-implantitis only (n = 34). A replication sample of 92 subjects who lost implants and 185 subjects successfully treated with implants were tested. DNA was extracted from buccal cells. Two genetic markers of
Statistically significant association between
This study provides evidence that the
The online version of this article (doi:10.1186/s12903-015-0018-6) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12903-015-0018-6
PubMed: 25887438
PubMed Central: 4367924
Affiliations:
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Casado</name><affiliation><nlm:aff id="Aff1">Dental School, Clinical Research Unit and Biology Institute, Federal Fluminense University - UFF, Niterói, RJ Brazil</nlm:aff><wicri:noCountry code="subfield">RJ Brazil</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Center of Clinical Research, Orthopedics and Traumatology National Institute – INTO, Rio de Janeiro, RJ Brazil</nlm:aff><wicri:noCountry code="subfield">RJ Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Aguiar, Diego P" sort="Aguiar, Diego P" uniqKey="Aguiar D" first="Diego P" last="Aguiar">Diego P. Aguiar</name><affiliation><nlm:aff id="Aff2">Center of Clinical Research, Orthopedics and Traumatology National Institute – INTO, Rio de Janeiro, RJ Brazil</nlm:aff><wicri:noCountry code="subfield">RJ Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Costa, Lucas C" sort="Costa, Lucas C" uniqKey="Costa L" first="Lucas C" last="Costa">Lucas C. Costa</name><affiliation><nlm:aff id="Aff3">Department of Dentistry, Federal Fluminense University - UFF, Niterói, RJ Brazil</nlm:aff><wicri:noCountry code="subfield">RJ Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Fonseca, Marcos A" sort="Fonseca, Marcos A" uniqKey="Fonseca M" first="Marcos A" last="Fonseca">Marcos A. Fonseca</name><affiliation><nlm:aff id="Aff3">Department of Dentistry, Federal Fluminense University - UFF, Niterói, RJ Brazil</nlm:aff><wicri:noCountry code="subfield">RJ Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Vieira, Thays Cs" sort="Vieira, Thays Cs" uniqKey="Vieira T" first="Thays Cs" last="Vieira">Thays Cs Vieira</name><affiliation><nlm:aff id="Aff2">Center of Clinical Research, Orthopedics and Traumatology National Institute – INTO, Rio de Janeiro, RJ Brazil</nlm:aff><wicri:noCountry code="subfield">RJ Brazil</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff4">Department of Biomedicine, Federal Fluminense University- UFF, Niterói, RJ Brazil</nlm:aff><wicri:noCountry code="subfield">RJ Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Alvim Pereira, Claudia Ck" sort="Alvim Pereira, Claudia Ck" uniqKey="Alvim Pereira C" first="Claudia Ck" last="Alvim-Pereira">Claudia Ck Alvim-Pereira</name><affiliation><nlm:aff id="Aff5">Department of Medicine, Health Sciences Center of Lagarto, Federal University of Sergipe (UFS), Lagarto, SE Brazil</nlm:aff><wicri:noCountry code="subfield">SE Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Alvim Pereira, Fabiano" sort="Alvim Pereira, Fabiano" uniqKey="Alvim Pereira F" first="Fabiano" last="Alvim-Pereira">Fabiano Alvim-Pereira</name><affiliation><nlm:aff id="Aff6">Department of Dentistry, Health Sciences Center of Lagarto, Federal University of Sergipe (UFS), Lagarto, SE Brazil</nlm:aff><wicri:noCountry code="subfield">SE Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Deeley, Kathleen" sort="Deeley, Kathleen" uniqKey="Deeley K" first="Kathleen" last="Deeley">Kathleen Deeley</name><affiliation wicri:level="2"><nlm:aff id="Aff7">Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Oral Biology, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Granjeiro, Jose M" sort="Granjeiro, Jose M" uniqKey="Granjeiro J" first="José M" last="Granjeiro">José M. Granjeiro</name><affiliation><nlm:aff id="Aff1">Dental School, Clinical Research Unit and Biology Institute, Federal Fluminense University - UFF, Niterói, RJ Brazil</nlm:aff><wicri:noCountry code="subfield">RJ Brazil</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff9">National Institute of Metrology (INMETRO), Niterói, RJ Brazil</nlm:aff><wicri:noCountry code="subfield">RJ Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Trevilatto, Paula C" sort="Trevilatto, Paula C" uniqKey="Trevilatto P" first="Paula C" last="Trevilatto">Paula C. Trevilatto</name><affiliation wicri:level="1"><nlm:aff id="Aff8">Center for Health and Biological Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Center for Health and Biological Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba</wicri:regionArea><wicri:noRegion>Curitiba</wicri:noRegion></affiliation></author><author><name sortKey="Vieira, Alexandre R" sort="Vieira, Alexandre R" uniqKey="Vieira A" first="Alexandre R" last="Vieira">Alexandre R. Vieira</name><affiliation wicri:level="2"><nlm:aff id="Aff7">Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Oral Biology, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff10">Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh</wicri:cityArea></affiliation></author></analytic><series><title level="j">BMC Oral Health</title><idno type="eISSN">1472-6831</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Peri-implantitis is a chronic inflammation, resulting in loss of supporting bone around implants. Chronic periodontitis is a risk indicator for implant failure. Both diseases have a common etiology regarding inflammatory destructive response. <italic>BRINP3</italic> gene is associated with aggressive periodontitis. However, is still unclear if chronic periodontitis and peri-implantitis have the same genetic background.</p><p>The aim of this work was to investigate the association between <italic>BRINP3</italic> genetic variation (rs1342913 and rs1935881) and expression and susceptibility to both diseases.</p></sec><sec><title>Methods</title><p>Periodontal and peri-implant examinations were performed in 215 subjects, divided into: healthy (without chronic periodontitis and peri-implantitis, n = 93); diseased (with chronic periodontitis and peri-implantitis, n = 52); chronic periodontitis only (n = 36), and peri-implantitis only (n = 34). A replication sample of 92 subjects who lost implants and 185 subjects successfully treated with implants were tested. DNA was extracted from buccal cells. Two genetic markers of <italic>BRINP3</italic> (rs1342913 and rs1935881) were genotyped using TaqMan chemistry. Chi-square (<italic>p</italic> < 0.05) compared genotype and allele frequency between groups. A subset of subjects (n = 31) had gingival biopsies harvested. The <italic>BRINP3</italic> mRNA levels were studied by C<sub>T</sub> method (2<sup>ΔΔCT</sup>). Mann–Whitney test correlated the levels of <italic>BRINP3</italic> in each group (<italic>p</italic> < 0.05).</p></sec><sec><title>Results</title><p>Statistically significant association between <italic>BRINP3</italic> rs1342913 and peri-implantitis was found in both studied groups (p = 0.04). The levels of <italic>BRINP3</italic> mRNA were significantly higher in diseased subjects compared to healthy individuals (p = 0.01).</p></sec><sec><title>Conclusion</title><p>This study provides evidence that the <italic>BRINP3</italic> polymorphic variant rs1342913 and low level of <italic>BRINP3</italic> expression are associated with peri-implantitis, independently from the presence of chronic periodontitis.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s12903-015-0018-6) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Albrektsson, T" uniqKey="Albrektsson T">T Albrektsson</name></author><author><name sortKey="Isidor, F" uniqKey="Isidor F">F Isidor</name></author><author><name sortKey="Lang, Np" uniqKey="Lang N">NP Lang</name></author><author><name sortKey="Karring, T" 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Neuspiel</name></author><author><name sortKey="Wasiak, S" uniqKey="Wasiak S">S Wasiak</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Brésil</li><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><noCountry><name sortKey="Aguiar, Diego P" sort="Aguiar, Diego P" uniqKey="Aguiar D" first="Diego P" last="Aguiar">Diego P. Aguiar</name><name sortKey="Alvim Pereira, Claudia Ck" sort="Alvim Pereira, Claudia Ck" uniqKey="Alvim Pereira C" first="Claudia Ck" last="Alvim-Pereira">Claudia Ck Alvim-Pereira</name><name sortKey="Alvim Pereira, Fabiano" sort="Alvim Pereira, Fabiano" uniqKey="Alvim Pereira F" first="Fabiano" last="Alvim-Pereira">Fabiano Alvim-Pereira</name><name sortKey="Casado, Priscila L" sort="Casado, Priscila L" uniqKey="Casado P" first="Priscila L" last="Casado">Priscila L. Casado</name><name sortKey="Costa, Lucas C" sort="Costa, Lucas C" uniqKey="Costa L" first="Lucas C" last="Costa">Lucas C. Costa</name><name sortKey="Fonseca, Marcos A" sort="Fonseca, Marcos A" uniqKey="Fonseca M" first="Marcos A" last="Fonseca">Marcos A. Fonseca</name><name sortKey="Granjeiro, Jose M" sort="Granjeiro, Jose M" uniqKey="Granjeiro J" first="José M" last="Granjeiro">José M. Granjeiro</name><name sortKey="Vieira, Thays Cs" sort="Vieira, Thays Cs" uniqKey="Vieira T" first="Thays Cs" last="Vieira">Thays Cs Vieira</name></noCountry><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Deeley, Kathleen" sort="Deeley, Kathleen" uniqKey="Deeley K" first="Kathleen" last="Deeley">Kathleen Deeley</name></region><name sortKey="Vieira, Alexandre R" sort="Vieira, Alexandre R" uniqKey="Vieira A" first="Alexandre R" last="Vieira">Alexandre R. Vieira</name><name sortKey="Vieira, Alexandre R" sort="Vieira, Alexandre R" uniqKey="Vieira A" first="Alexandre R" last="Vieira">Alexandre R. Vieira</name></country><country name="Brésil"><noRegion><name sortKey="Trevilatto, Paula C" sort="Trevilatto, Paula C" uniqKey="Trevilatto P" first="Paula C" last="Trevilatto">Paula C. Trevilatto</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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